When Julie Baker is diagnosed with multiple sclerosis and told her vision might get worse, she struggles to accept she’s going blind, and Javier Torres becomes frustrated with others' responses to his neurosensorial hearing loss.

Some harsh words from Sarah Kucenas’ high school swim coach shake her confidence and she gives up her dream of being a pediatric neurosurgeon, and when Michael Herrera’s COVID turns into long COVID, he struggles to feel like himself until he starts birding.

When Kaze Wong chooses the path of physics over high jumping, he feels like he betrayed a part of himself, and even though Micaela Martinez spent most of her life working towards becoming a professor, she still doesn’t feel comfortable in the academic world, so she secretly starts rapping.

Rich Tackenberg is skeptical when a psychic tells him there’s something wrong with his car, and science journalist Katherine J. Wu interviews neuroscientists Susana Martinez-Conde and Stephen Macknik to get a better idea of how psychics, like the one from Rich Tackenberg’s story, operate.

Pediatrician Ken Haller goes off script when a father comes into the exam room with his young son, and after years of Mikala Jamison’s dad helping her with her mental health struggles, the roles are reversed when her father is diagnosed with early onset Alzheimers.

While staying with host family in an unfamiliar city, Andrew Spink wakes up to find he can’t swallow, and distracted by thoughts of his career, entomologist Ralph Washington, Jr. gets swarmed by mosquitos.

As a new science teacher, Zeke Kossover is determined to capture the attention of his students, and while on a field expedition in Kenya, Evan Wilson is tasked with the seemingly impossible job of figuring out the role of dust in wearing down herbivore teeth.

When Colleen McDermott signs up to be a forestry conservationist for the summer, they soon notice that none of their colleagues look like them, and on Pete McCorvey’s first deployment in the United States Navy, he is dreading the part of training where he gets pepper sprayed.

As a teenager growing up in Iran Yasamin Jodat hears about a robotics competition at the local boys' school, and she is determined to do whatever it takes to be part of it, and a third cancer diagnosis threatens to ruin JulieAnn Villa's love of running.

Discouraged by the medical approach to pregnancy, Julia Whitehouse decides to have a home birth, and when Nessa Goldman splits with her husband, her dream of having children by age 35 is in jeopardy.